Cas No. |
Product name |
128517-07-7 |
Romidepsin (FK228, Depsipeptide) |
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Romidepsin (FK228, depsipeptide) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively |
873436-91-0 |
PU-H71 |
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PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM |
929016-96-6 |
Pracinostat (SB939) |
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SB939 is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Phase 2. |
1062243-51-9 |
Ro3280 |
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RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM. |
864814-88-0 |
Resminostat |
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Resminostat dose-dependently and selectively inhibits HDAC1/3/6 with IC50 of 42.5 nM/50.1 nM/71.8 nM, less potent to HDAC8 with IC50 of 877 nM. |
1252003-15-8 |
Tubastatin A |
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Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). |
1316214-52-4 |
Rocilinostat (ACY-1215) |
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Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity again... |
537049-40-4 |
Tubacin |
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Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1. |
1310693-92-5 |
Tubastatin A HCL |
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Tubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). |
414864-00-9 |
Belinostat (PXD101) |
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Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. |